Hydrogenation In Pharmaceutical Industry
Hydrogenation has been widely accepted by the chemical & the pharmaceutical industries since the 1960s, because it is a very attractive technology with hydrogen as a medium which is both environmental & cost friendly.
The hydrogenation process is basically used to produce a chiral using the homogeneous asymmetric catalysis technology providing organic compounds such as highly versatile R-3-Quinuclidinol (C7H13NO), which can be used as a chiral building block, intermediates of APIs, synthon in a wide variety of processes & reactions. Many products, raw materials, or ingredients can be processed, preserved, or solidified by hydrogenation. Products processed using the hydrogenation process include ammonia, fuels (hydrocarbons), alcohols, medicines, margarine, polyols, different polymers, and chemicals (hydrogen chloride and hydrogen peroxide).
There are two different types of industrial hydrogenation, one being batch hydrogenation reactor & the second one is Continuous Flow / Tubular / Fixed Bed Reactor. A heating element or jacket, an agitator, and a huge pressurised vessel are all components of a batch hydrogenation reactor. The catalysts are suspended in the substrate, which has been heated. Following the pressure-induced introduction of hydrogen, agitation is utilised to guarantee that the catalyst particles and chemical starting material are thoroughly mixed. Heat is needed to start the process, however once hydrogenation has started in earnest, it could turn exothermic. The catalyst particle is subsequently filtered out of the hydrogenated material. Pharmaceutical production and the preparation of edible lipids both frequently use this hydrogenation technique. With batch reactors, the pace at which hydrogen is delivered to the reactor must change based on the degree of hydrogenation completion to offer the best results.
Amar specializes in designing & manufacturing hydrogenation reactors in India over the past 20 years. We manufacture hydrogenators from 100 ml volume to 10,000 ltr volume with up to 350 bar and 500°C in SS 316, Hastelloy B / C, Inconel, Monel, Titanium. We provide customized solutions to your specific requirements.