The MACFLO™ reactor (Multiphasic-Agitated-Contactor) is a patented, high-intensity continuous flow reactor engineered for the most demanding multiphase and viscous reaction systems. Unlike conventional tubular or staged reactors, MACFLO™ uses a single-cell, mechanically agitated design that generates intense, controlled turbulence throughout the entire reactor volume. This enables exceptional heat and mass transfer while maintaining a narrow residence time distribution equivalent to multiple CSTRs in series.
Its advanced impeller system produces powerful von Kármán vortices, ensuring uniform dispersion of solids, efficient gas–liquid contact, and reliable handling of highly viscous or high-solids slurries. Capable of operating at extremely high pressures and temperatures, the MACFLO™ reactor excels in applications such as liquid–liquid extraction, high-pressure hydrogenation, polymerization, and continuous crystallization. The result is a compact, scalable reactor platform that delivers superior selectivity, safety, and productivity for complex continuous flow processes.
A mechanically agitated design generates controlled turbulence throughout the reactor, delivering exceptional mixing without internal partitions or staged compartments.
Designed to process viscous media and high solid loadings (up to ~35% w/v) with reliable suspension and no channeling or fouling.
Achieves narrow residence time distribution equivalent to multiple CSTRs in series while operating at very high pressure and temperature.
Single-cell construction without internal baffles or stages simplifies cleaning, inspection, and changeover—ideal for multiproduct campaigns and GMP-compliant operations.
Dicyandiamide (DCDA), also known as 2-Cyanoguanidine, is a highly alkaline, white crystalline solid and a nitrile derivative of guanidine. It is a dimer of cyanamide, which serves as its precursor during synthesis. Dicyandiamide is highly soluble in water and exhibits good solubility in polar solvents such as acetone and alcohol, but it is insoluble in nonpolar organic solvents.
Read MoreThe MACFLO™ (Multiphasic-Agitated-Contactor) Reactor is a patented, single-cell, mechanically agitated continuous reactor designed to intensify complex multiphase chemistries. It overcomes the limitations of conventional slurry flow reactors by delivering uniform mixing, superior mass and heat transfer, and predictable residence times—even in viscous systems, high solid slurries, and gas–liquid–solid reactions.
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Extreme Operating Window: Engineered for the most demanding chemistries, the MACFLO™ reactor operates at pressures up to 350 bar and temperatures up to 500°C. This capability unlocks many challenging applications, from high-pressure hydrogenations and carboxylations to hydrothermal liquefaction.
Superior Mass and Heat Transfer: The active agitation system dramatically enhances both heat and mass transfer coefficients. This ensures precise, uniform temperature control for highly exothermic or endothermic reactions and drives rapid mass transfer between phases, which is critical for gas-liquid reactions and liquid-liquid extractions.
Yes. MACFLO™ is purpose-built for slurry flow reactors handling:
Its powerful mechanical agitation keeps solids uniformly suspended, preventing clogging, fouling, and agglomeration—common failure modes in other continuous slurry reactors.
The active agitation system dramatically increases both mass transfer and heat transfer coefficients. This allows:
These advantages make MACFLO™ ideal for high-pressure catalysis and liquid-liquid extraction.
Absolutely. MACFLO™ functions as a high-intensity liquid-liquid extractor, providing intimate phase contact and large interfacial area. It enables fast, efficient extraction even in viscous or multiphase systems where conventional extractors or static mixers struggle.
Continuous crystallization offers significant advantages over traditional batch methods, including enhanced safety, higher product quality, and faster reaction cycles. However, in conventional batch crystallizers, achieving a consistent product is difficult due to uneven mixing and unstable temperature and concentration conditions. These limitations create localized zones of high supersaturation, leading to uncontrolled nucleation and a wide, unpredictable crystal size distribution, which can negatively impact downstream processing.
The MACFLO™ Reactor overcomes these challenges by applying intense and controlled process conditions throughout the entire reactor volume, making it ideally suited for continuous crystallization processes such as melt crystallization. Its advanced impeller system generates powerful vortices that deliver rapid and homogeneous mixing. This active agitation maintains uniform temperature and concentration, prevents localized supersaturation, and promotes even, controlled crystal growth, resulting in high-quality crystals with a consistent and desirable particle size distribution.
Crystallization is inherently a slurry-based process, and the MACFLO™ Reactor is specifically engineered to handle high solid loadings up to 35% w/v and viscous media without the risk of clogging that affects many other continuous reactor types. The strong agitation keeps crystals uniformly suspended, preventing agglomeration and ensuring smooth, stable operation.
In addition, the MACFLO™ Reactor exhibits near plug-flow behavior, equivalent to 10 CSTRs in series, resulting in a narrow residence time distribution. This ensures that every crystal nucleus experiences identical process conditions for the same duration, enabling consistent crystal growth and delivering a final product with a tight, predictable crystal size distribution.
While the MACFLO™ reactor is a game-changer for liquid liquid extraction and viscous systems, its fundamental design makes it a superior choice for a broad array of challenging multiphase chemistries. Its ability to ensure intimate contact between phases under precise control unlocks new efficiencies across numerous applications :
